A GENETIC SWITCH MARK PTASHNE PDF

Start your review of A Genetic Switch, Phage Lambda Revisited Write a review Jan 18, Dan rated it it was amazing A detailed look at gene regulation in the simplest of model organisms, a virus which infects the E. Coli bacterium. Its 2, base pair genome is simple enough that it can be understood in its entirety. Two anecdotes: - The width of an alpha helix is just right to fit inside the major groove of the DNA double helix. This facilitates proteins binding specifically to DNA sequences and modifying their behavior. Whether this is an essential feature in the evolution of proteins and DNA is unclear.

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This edition is a reprint of the original text, together with a new chapter updating the story to Contents Chapter 1. The Master Elements of Control Chapter 2. More importantly, the detailed studies summarized in these chapters that relate properties of the molecular components to the function of the switch establish a high standard for the systems biology of more complex organisms.

Periodic update of a book like this is important as a reminder of the level of our understanding of a system, in this case lambda, and of how we achieved that understanding. Switch back! The author has a talent for simplifying but not oversimplifying complicated ideas, he describes the theory and its experimental basis in a straightforward and plainspoken way, and he illustrates his points with drawings that contain just the right amount of detail.

Connoisseurs will appreciate the new chapter on recent developments, in which some parts of the original picture are redrawn and others filled in I strongly recommend the new edition of A Genetic Switch to students of molecular biology from the advanced undergraduate level up. The author and publisher are to be commended for supplying this volume at such a reasonable price.

His research and The Genetic Switch are both characterized by an insistence on asking and pursuing critical questions until an unusual experimental observation is completely understood, often resulting in unexpected new insights This current edition of The Genetic Switch is compelling both because of the new information it contains and because the lessons of the version are timeless.

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A Genetic Switch, Phage Lambda Revisited

This edition is a reprint of the original text, together with a new chapter updating the story to Contents Chapter 1. The Master Elements of Control Chapter 2. More importantly, the detailed studies summarized in these chapters that relate properties of the molecular components to the function of the switch establish a high standard for the systems biology of more complex organisms. Periodic update of a book like this is important as a reminder of the level of our understanding of a system, in this case lambda, and of how we achieved that understanding. Switch back!

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A GENETIC SWITCH MARK PTASHNE PDF

This edition is a reprint of the original text, together with a new chapter updating the story to More importantly, the detailed studies summarized in these chapters that relate properties of the molecular components to the function of the switch establish a high standard for the systems biology of more complex organisms. Periodic update of a book like this is important as a reminder of the level of our understanding of a system, in this case lambda, and of how we achieved that understanding. Switch back! The author has a talent for simplifying but not oversimplifying complicated ideas, he describes the theory and its experimental basis in a straightforward and plainspoken way, and he illustrates his points with drawings that contain just the right amount of detail. Connoisseurs will appreciate the new chapter on recent developments, in which some parts of the original picture are redrawn and others filled in

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Chandrima Dey added it Sep 03, A repressor dimer binds through its amino domains to a 17 base pair. Account Options Sign in. His research and The Genetic Switch are both characterized by an insistence on asking and pursuing critical questions until an unusual experimental observation is completely understood, often resulting in unexpected new insights Pragati rated it really liked it Sep 18, This edition is a reprint of the original text, together with a new chapter updating the pashne to Phage Lambda and Higher Organisms. One person found this helpful. To see what your friends thought of this book, please sign up. Write a customer review.

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