ANTIGENO CARCINOEMBRIONARIO CEA PDF

Respiratory diseases - eg, pleural inflammation, pneumonia. Normal range Individual laboratory normal ranges vary but CEA level is usually deemed to be normal at 2. Increasing levels of CEA suggestive of active disease may be more clinically helpful than absolute level[ 4 ]. Sensitivity[ 4 , 5 ] Sensitivity in early-stage colorectal cancer is very low and increases with the stage of the disease.

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Respiratory diseases - eg, pleural inflammation, pneumonia. Normal range Individual laboratory normal ranges vary but CEA level is usually deemed to be normal at 2. Increasing levels of CEA suggestive of active disease may be more clinically helpful than absolute level[ 4 ]. Sensitivity[ 4 , 5 ] Sensitivity in early-stage colorectal cancer is very low and increases with the stage of the disease.

Studies reporting sensitivity vary in the cut off for what constitutes a normal CEA level so results are varied. Indications for CEA measurement Colorectal cancer[ 2 , 5 ] Due to the low sensitivity and specificity of the CEA test, it is not recommended that it be used for screening of healthy individuals or for the diagnosis of early colorectal cancer.

A CEA level should be ordered only after malignancy has been confirmed. Prognosis: The CEA test is of much more use in determining prognosis than it is as an early diagnostic test for colon cancer. CEA levels are more likely to be elevated in advanced disease.

Staging: CEA in combination with other tumour markers eg, mucin tumour markers CA, CA can be used in pre-operative staging and thereby assist in the planning of the type of surgery required and future management options[ 6 ]. Monitoring treatment: The major role for CEA levels is in following patients for relapse after intended curative treatment of colorectal cancer. CEA levels typically return to normal within four to six weeks after successful surgical resection.

The CEA level can also be used to assess the response to chemotherapy. The National Institute for Health and Care Excellence NICE recommends that for people who have had potentially curative surgical treatment for non-metastatic colorectal cancer, follow-up for detection of local recurrence and distant metastases for the first three years should include CEA and CT scan of the chest, abdomen and pelvis[ 7 ].

Clinical trials have shown improvement in survival after five years in patients who underwent CEA monitoring as part of post-treatment management[ 4 ]. However, a Cochrane review found no overall survival benefit for intensifying the follow-up of patients after curative surgery for colorectal cancer. More participants were treated with salvage surgery with curative intent in the intensive follow-up groups, but this was not associated with improved survival.

Harms related to intensive follow-up and salvage therapy were not well reported[ 8 ]. Normal levels do not necessarily indicate that recurrence has not occurred[ 9 ]. Breast cancer Similar considerations apply to the diagnosis of breast cancer. The sensitivity of CEA is too low for it to be used as a primary diagnostic test. Although the prognosis for operable breast cancers is reportedly worse if serum CEA and cancer antigen CA levels are above normal, the usefulness of this prognosis is limited due to the low sensitivity and specificity.

In addition, the optimal cut-off levels remain unknown[ 10 ]. Some studies have shown that, in conjunction with other tumour markers CA Predicting response to chemotherapy[ 13 ].

It is not recommended in the routine surveillance of breast cancer and should not be used in isolation for monitoring in advanced disease[ 4 ].

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MARCADOR TUMORAL ANTÍGENO CARCINOEMBRIÓNICO (CEA)

O controle de qualidade foi realizado automaticamente, em intervalos definidos. Figura 1. Abstract Objective: this research was based on the serum determination of important biological markers, in oncologic individuals, for a possible prognostic detection of colorectal cancer, such as CEA carcinoembryonic antigen , aminotransferases ALT and AST and total bilirubin TB and its direct DB and indirect IB fractions. The cross-sectional cohort study was adopted to evaluate the prevalence of CEA positivity, correlated with elevated serum levels of bilirubins and aminotransferases. What is the impact of chronic systemic inflammation such as rheumatoid arthritis on mortality following cancer? Ann Rheum Dis.

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Dosagem do CEA (antígeno carcinoembrionário) e câncer de intestino

Doctor in stiinte medicale Antigenul carcinoembrionar CEA a fost descris pentru prima data in de catre Gold si Freedman la un pacient cu carcinom colorectal. Antigenul carcinoembrionar CEA este unul dintre antigenele oncofetale produse in timpul vietii embrionare si a dezvoltarii fetale. Sinteza antigenului carcinoembrionar CEA este codificata de un grup de cel putin 14 - 16 gene care dirijeaza si sinteza altor glicoproteine CEA-like. Aceste gene sunt denumite "familia genelor CEA". Investigatiile cu anticorpi monoclonali au pus in evidenta cel putin 6 determinanti antigenici diferiti. In plus, pot apare si alte diferente individuale datorate diferitelor tipuri de glicozilare.

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Antigene Carcino Embrionario - CEA

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